TB-500

TB-500 is a synthetic version of a 43-amino acid peptide fragment found at high concentrations in platelets and wound fluid. Thymosin Beta-4, the parent protein, was first isolated from calf thymus in the 1960s and has since been detected in virtually every mammalian cell type studied. TB-500 corresponds to the biologically active core region responsible for the compound's principal research-characterized activities.

The mechanism underlying TB-500's studied effects centers on its ability to sequester G-actin monomers via a central LKKTET motif, influencing actin polymerization dynamics and consequently cell migration and cytoskeletal organization. Beyond actin interactions, published research in animal models has examined TB-500's role in promoting angiogenesis through VEGF-related pathways, modulating inflammation via downregulation of inflammatory cytokines, and supporting differentiation of precursor cell populations.

Notably, TB-500 has shown systemic activity in preclinical cardiac models following remote application—a property tied to its small size and ability to traverse tissue barriers. APEX 100 supplies TB-500 as ≥99% HPLC-verified lyophilized powder with a comprehensive COA included with every order.

For research and laboratory use only. Not for human consumption.

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