GHK-Cu

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is among the most studied naturally occurring copper-binding peptides in existence. First isolated from human plasma albumin by Dr. Loren Pickart in 1973, this tripeptide-copper complex has since accumulated a research record spanning wound biology, gene expression modulation, antioxidant signaling, and tissue remodeling—a breadth unusual for a molecule of just three amino acids.

GHK-Cu exerts its studied effects through high-affinity copper(II) chelation, forming a stable 1:1 complex that facilitates copper delivery to cells and enzymes with copper-dependent activity, including lysyl oxidase (critical for collagen crosslinking) and superoxide dismutase. At the genomic level, published microarray analysis suggests GHK-Cu influences the expression of over 4,000 human genes, including networks governing inflammation resolution, DNA repair signaling, and extracellular matrix remodeling.

It is supplied as a lyophilized blue powder—the characteristic color deriving from the Cu²⁺ complex—with ≥99% HPLC-verified purity. APEX 100's GHK-Cu is independently tested for identity and endotoxin levels, with a full Certificate of Analysis included with every order.

For research and laboratory use only. Not for human consumption.