Epithalon

Epithalon (Epitalon; Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled after epithalamin, an endogenous extract of the pineal gland first characterized by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. The pineal gland produces epithalamin at declining rates with age in animal models, an observation that prompted decades of research into what synthetic analogs might reveal about aging biology.

The primary mechanism under study is telomerase activation. Published cell culture work has documented Epithalon's ability to upregulate telomerase reverse transcriptase (hTERT) expression in human somatic cells that do not ordinarily express telomerase, leading to measurable telomere elongation in vitro. Whether this in-vitro effect translates meaningfully to tissue-level aging dynamics in vivo is an open and active research question—which is precisely what makes Epithalon compelling for longevity biology investigation.

Beyond telomerase, Khavinson's group has published work on Epithalon's interactions with melatonin production and circadian regulation in animal models, and its influence on antioxidant enzyme expression. APEX 100 supplies Epithalon as ≥99% HPLC-verified lyophilized powder (40mg per vial, MW ~390.35 Da) with a full Certificate of Analysis.

For research and laboratory use only. Not for human consumption.

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